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Independent of loss of kidney function, a rise in BUN may also occur as a result of hypercatabolism from the excess breakdown of amino acids

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Ahn YH, Lee JS, Chang YT

Natural compounds as modulators of NADPH oxidases

Second, knockout of alsin in mice is not sufficient to trigger motor neuron degeneration, but neurons cultured from these animals are more susceptible to oxidative stress (Cai et al., 2006

Free Radic Biol Med 18:321336 Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage